Atypical ductal hyperplasia on vacuum-assisted breast biopsy: suspicion for ductal carcinoma in situ can stratify patients at high risk for upgrade

作者：Allison Kimberly H^*; Eby Peter R; Kohr Jennifer; DeMartini Wendy B; Lehman Constance D

来源：Human Pathology, 2011, 42(1): 41-50.

DOI：10.1016/j.humpath.2010.06.011

• Atypical ductal hyperplasia
• ADH
• Breast Core needle biopsy
• Ductal carcinoma in situ
• Breast cancer
• Suspicious

We evaluated 97 cases of review-confirmed atypical ductal hyperplasia found on stereotactic vacuum-assisted breast biopsy of suspicious calcifications The number and size of foci of atypical ductal hyperplasia and presence of a micropapillary component were noted In addition, we recorded if a case was considered "atypical ductal hyperplasia suspicious for ductal carcinoma in situ' using specific qualitative criteria The upgrade rate was 20 6% (20/97) for all cases and 48% (12/25) for cases suspicious for ductal carcinoma in situ Suspicion for ductal carcinoma in situ was found to be a strong predictor of upgrade with an-odds ratio of 7 4 (P = 0003) Suspicious cases with nuclear features bordering on intermediate nuclear grade had the highest upgrade rate of 75% (6/8) Cases with 3 foci had significantly higher upgrade rates (28%) than those with less than 3 foci (11%), but focal atypical ductal hyperplasia did upgrade (P = 04) In conclusion, qualitative fe

• 出版日期2011-1