Nitric Oxide Sensing through Azo-Dye Formation on Carbon Dots

作者：Bhattacharya Sagarika; Sarkar Rhitajit; Chakraborty Biswarup; Porgador Angel; Jelinek Raz^*

来源：ACS Sensors, 2017, 2(8): 1215-1224.

DOI：10.1021/acssensors.7b00356

• carbon dots
• fluorescence quenching
• nitric oxide detection
• azo dye formation
• polymerization of C-dots

Carbon dots (C-dots) prepared through heating of aminoguanidine and citric acid enable bimodal (colorimetric and fluorescence) detection of nitric oxide (NO) in aqueous solutions. The C-dots retained the functional units of aminoguanidine, which upon reaction with NO produced surface residues responsible for the color and fluorescence transformations. Notably, the aminoguanidine/citric acid C-dots were noncytotoxic, making possible real-time and high sensitivity detection of NO in cellular environments. Using multiprong spectroscopic and chromatography analyses we deciphered the molecular mechanism accounting for the NO-induced structural and photophysical transformations of the C-dots, demonstrating for the first time N-2 release and azo dye formation upon the C-dots' surface.

• 出版日期2017-8