Association between PCSK9 and LDLR gene polymorphisms with coronary heart disease: Case-control study and meta-analysis

作者：Zhang, Lina^*; Yuan, Fang; Liu, Panpan; Fei, Lijuan; Huang, Yi; Xu, Limin; Hao, Lingmei; Qiu, Xujun; Le, Yanping; Yang, Xi; Xu, Weifeng; Huang, Xiaoyan; Ye, Meng; Zhou, Jianqing; Lian, Jiangfang; Duan, Shiwei

来源：Clinical Biochemistry, 2013, 46(9): 727-732.

DOI：10.1016/j.clinbiochem.2013.01.013

• PCSK9
• LDLR
• LDL-C
• SNP
• Meta-analysis

Objective: To explore the association of rs11206510 (PCSK9 gene) and rs1122608 (LDLR gene) polymorphisms with coronary heart disease (CHD) in Han Chinese.
Methods: A total of 813 participants (290 CHD cases, 193 non-CHD controls and 330 healthy controls) were recruited in the case-control study. DNA genotyping was performed on the SEQUENOM (R) Mass-ARRAY iPLEX (R) platform. chi(2)-test was used to compare the genotype distribution and allele frequencies. Two meta-analyses were performed to establish the association between the two polymorphisms with CHD.
Results: No significant associations between the two SNPs and the risk of CHD were observed in the present study. The meta-analysis of rs11206510 of PCSK9 gene comprises 11 case-control studies with a total of 69,054 participants. Significant heterogeneity was observed in Caucasian population in subgroup analysis of the association studies of rs11206510 with CHD (P = 0.003, I-2 = 67.2%). The meta-analysis of LDLR gene rs1122608 polymorphism comprises 7 case-control studies with a total of 20,456 participants and the heterogeneity of seven studies was minimal (P = 0.148, I-2 = 36.7%).
Conclusion: The results of the meta-analyses indicated that both SNPs were associated with CHD in Caucasians (P<0.05) but not in Asians. The results from our case-control study and meta-analyses might be explained by genetic heterogeneity in the susceptibility of CHD and ethnic differences between Asians and Caucasians.

• 出版日期2013-6
• 单位宁波大学; 宁波市医疗中心李惠利医院