Mild and metal-free trifluoromethylation and pentafluoroethylation of gem-difluoroalkenes with TMSCF3 and TMSCF2CF3

作者：Jin, Guanyi; Zhang, Xuxue; Fu, Dan; Dai, Wenpeng; Cao, Song^*

来源：Tetrahedron, 2015, 71(41): 7892-7899.

DOI：10.1016/j.tet.2015.08.016

• Trifluoromethylation
• Pentafluoroethylation
• gem-Difluoroalkenes
• (Trifluoromethyl)trimethylsilane
• (Pentafluoroethyl)trimethylsilane

A direct and efficient approach for the trifluoromethylation and pentafluoroethylation of 1,1-diary1-2,2-difluoroethenes with TMSCF3 and TMSCF2CF3 in the presence of TBAF was developed. The reactions proceeded smoothly under mild reaction conditions to give the corresponding monotrifluoromethylated, bistrifluoromethylated, monopentafluoroethylated and bispentafluoroethylated products in fair to good yields, respectively, without the addition of metal catalyst.

• 出版日期2015-10-14
• 单位华东理工大学