Accumulated brisk walking reduces arterial stiffness in overweight adults: Evidence from a randomized control trial

作者：Kearney Therese M; Murphy Marie H; Davison Gareth W; O' Kane Maurice J; Gallagher Alison M^*

来源：Journal of the American Society of Hypertension, 2014, 8(2): 117-126.

DOI：10.1016/j.jash.2013.10.001

• Pulse wave velocity
• nitric oxide
• exercise
• moderate activity

Arterial stiffness is a major contributor to the development of atherosclerosis and consequently cardiovascular disease. This study aimed to examine whether 6 months of accumulated (3 x 10 minutes, 5 days/week) brisk walking was sufficient to reduce arterial stiffness in sedentary, overweight individuals. Seventy-seven individuals (19 men, 58 women; age, 30-55 years) were randomly allocated to one of three groups; two groups completed 30 minutes of accumulated walking with either monthly or weekly telephone support; the third group (control) performed stretching exercises. The walking groups were combined and telephone support included as a covariate. Anthropometry, blood pressure (BP), blood lipids, pulse wave velocity (PWV), and NOx (surrogate marker for nitric oxide) were measured at baseline, post-intervention and 4 months post-intervention. No changes were observed for anthropometry, BP, or lipids. However, at the end of the intervention, there was a decrease in PWV (P %26lt; .001) accompanied by an increase in NOx (P %26lt; .001), with changes maintained 4 months post-intervention. A strong negative correlation between PWV and NOx was also observed (P %26lt; .001; r = 0.65). A lifestyle approach to meeting current physical activity guidelines results in favorable alterations in arterial function in overweight individuals. J Am Soc Hypertens 2014;8(2):117-126.

• 出版日期2014-2