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摘要
Quinone oxidoreductase (NQO1) C609T polymorphisms have been implicated in acute myeloblastic leukemia (AML) risk, but previously published studies are inconsistent and recent meta-analyses have not been adequate. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. The quality of studies was evaluated by using the Newcastle-Ottawa Scale (NOS). Crude ORs with 95% CIs were used to assess the strength of association between the NQO1 C609T polymorphisms and AML risk. A total of 14 studies including 2,245 cases and 3,310 controls were involved in this meta-analysis. Overall, significantly elevated AML risk was associated with NQO1 C609T variant genotypes when all studies were pooled into the meta-analysis (TT vs. CC: OR=1.44, 95% CI=1.15-1.81; dominant model: OR=1.35, 95% CI=1.09-1.68). In the subgroup analysis by ethnicity, significantly increased risks were found for Asians (OR=1.47, 95% CI=1.13-1.93, P=0.005, I-2=48.4%, P=0.071 for heterogeneity). When stratified by studies of adults or children, statistically significantly elevated risks were found among adults (OR=1.37, 95% CI=1.06-1.76, P=0.017, I-2=42.2%, P=0.097 for heterogeneity). The accumulated evidence indicates that NQO1 C609T seems to confer a risk factor for AML among Asians and adults. Significant between-study heterogeneity was observed, thus more studies based on larger case-control population are required to further evaluate the role of NQO1 C609T polymorphism in AML. Pediatr Blood Cancer 2014;61:771-777.
- 出版日期2014-5
- 单位广西医科大学
