Protein folding by %26apos;levels of separation%26apos;: A hypothesis

作者：Greene Lesley H^*; Grant Terri M

来源：FEBS Letters, 2012, 586(7): 962-966.

DOI：10.1016/j.febslet.2012.02.040

• Chymotrypsin inhibitor 2
• Long-range interaction
• Network
• Nucleation-condensation model
• Protein folding
• Transition-state

The protein folding process has been studied both computationally and experimentally for over 30 years. To date there is no detailed mechanism to explain the formation of long-range interactions between the transition and native states. Long-range interactions are the principle determinants of the tertiary structure. We present a theoretical model which proposes a mechanism for the acquisition of these interactions as they form in a modified version of %26apos;degrees of separation%26apos;, that we term %26apos;levels of separation%26apos;. It is based on the integration of network science and biochemistry.

• 出版日期2012-4-5