Asymmetric NHC-Catalyzed Redox alpha-Amination of alpha-Aroyloxyaldehydes

作者：Taylor James E; Daniels David S B; Smith Andrew D^*

来源：Organic Letters, 2013, 15(23): 6058-6061.

DOI：10.1021/ol402955f

Asymmetric alpha-amination through an N-heterocyclic carbene (NHC)-catalyzed redox reaction of alpha-aroyloxyaldehydes with N-aryl-N-aroyldiazenes to form alpha-hydrazino esters with high enantioselectivity (up to 99% ee) is reported. The hydrazide products are readily converted into enantioenriched N-aryl amino esters through samarium(II) iodide mediated N-N bond cleavage.

• 出版日期2013-12-6