Antiretroviral drug concentrations in the male and female genital tract: implications for the sexual transmission of HIV

作者：Taylor Stephen^*; Davies Sophia

来源：Current Opinion in HIV and AIDS, 2010, 5(4): 335-343.

DOI：10.1097/COH.0b013e32833a0b69

• antiretroviral drug concentrations
• female genital tract
• HIV-1
• male genital tract

Purpose of review
To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract.
Recent findings
Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentrations achieved vary considerably depending on the class of drug studied, the sampling techniques used and the times samples are obtained.
Summary
There appear to be several patterns of drug penetration into the male and female genital tract. In addition there appear to be different patterns of genital shedding under the influence of antiretroviral therapy. What effect these factors will have on the sexual transmission of HIV or the evolution and transmission of resistant HIV remains to be seen.

• 出版日期2010-7