A Facile Synthesis of Discoidal Lipid Bilayer Nanostructure by Association of a Cationic Amphiphilic Polyelectrolyte

作者：Cho Eun Chul^*

来源：Bulletin of the Korean Chemical Society, 2012, 33(7): 2187-2192.

DOI：10.5012/bkcs.2012.33.7.2187

• Lipid bilayer nanostructures
• Cationic amphiphilic polymer
• Hollow hemisphere
• Disc

This study presents a facile way synthesizing disc-like lipid bilyaer nanostructures with a cationic amphiphilic polyelectrolyte. The cationic amphiphilic polyelectrolyte was in a form of partially quarternized copolymer and was synthesized with 2-(dimethylamino)ethyl methacrylate and stearyl methacrylate. At some concentration ranges of the polymer, the addition of the polymer to lipid components during the preparation of bilayer nanostructures resulted in discs with a fairly high yield (similar to 99%). The mechanism for the formation of the nanostructures was discussed based on the physical properties of these nanostructures and by comparing the nanostructures obtained with an anionic amphiphilic polyelectrolyte.

• 出版日期2012-7-20