Hes1: a key role in stemness, metastasis and multidrug resistance

作者：Liu, Zi-Hao; Dai, Xiao-Meng; Du, Bin^*

来源：Cancer Biology and Therapy, 2015, 16(3): 353-359.

DOI：10.1080/15384047.2015.1016662

• cancer stem cell
• chemotherapy resistance
• Hes1
• metastasis
• Notch signaling pathway
• non-canonical Notch
• CSCs
• cancer stem cells
• EMT
• epithelial-mesenchymal transition
• MASH-1
• Mammalian achaete-scute homolog-1
• bHLH
• basic helix-loop-helix
• TLE
• transducin-like Enhancer of split
• HDACs
• histone deacetylases
• dnMAM
• dominant-negative mastermind
• Runx2
• Runt-related protein 2
• ABC
• ATP-binding cassette
• NICD
• Notch intracellular domain
• CSL
• CBF1
• Suppressor of Hairless
• Lag1
• MAML

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs), metastasis and antagonizing drug-induced apoptosis. Pathways that are involved in the up-regulation of Hes1 level canonically or non-canonically, such as the Hedgehog, Wnt and hypoxia pathways are frequently aberrant in cancer cells. Here, we summarize the recent data supporting the idea that Hes1 may have an important function in the maintenance of cancer stem cells self-renewal, cancer metastasis, and epithelial-mesenchymal transition (EMT) process induction, as well as chemotherapy resistance, and conclude with the possible mechanisms by which Hes1 functions have their effect, as well as their crosstalk with other carcinogenic signaling pathways.

• 出版日期2015-3
• 单位暨南大学