A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

作者：Vichier Guerre Sophie; Dugue Laurence; Pochet Sylvie^*

来源：Tetrahedron Letters, 2014, 55(46): 6347-6350.

DOI：10.1016/j.tetlet.2014.09.104

• 4(5)-Arylimidazoles
• C-arylation
• Microwave assisted synthesis
• Suzuki-Miyaura cross-coupling
• Boronic acids

A simple and rapid access to a variety of 4(5)-arylated imidazoles via palladium-catalyzed Suzuki-Miyaura cross-coupling reaction is described. Coupling parameters were screened for efficient C-4 arylation of N-unprotected 4-iodoimidazole with a broad range of boronic acids under microwave irradiation. Twenty-one imidazole derivatives were synthesized in modest to excellent yields in short reaction times.

• 出版日期2014-11-12