A direct and versatile access to alpha,alpha-disubstituted 2-pyrrolidinylmethanols by Sml(2)-mediated reductive coupling

作者：Burchak Olga N; Philouze Christian; Chavant Pierre Yves^*; Py Sandrine

来源：Organic Letters, 2008, 10(14): 3021-3023.

DOI：10.1021/ol800982n

Various alpha,alpha-disubstituted 2-pyrrolidinylmethanols are efficiently prepared in a single step from ketones using a Sml(2)-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-alpha,alpha-diphenylprolinol is also easily prepared and resolved.

• 出版日期2008-7-17