Association of RIP2 gene polymorphisms and systemic lupus erythematosus in a Chinese population

作者：Li, Jing; Tian, Jing; Ma, Yan; Cen, Han; Leng, Rui-Xue; Lu, Man-Man; Chen, Gui-Mei; Feng, Chen-Chen; Tao, Jin-Hui; Pan, Hai-Feng; Ye, Dong-Qing^*

来源：Mutagenesis, 2012, 27(3): 319-322.

DOI：10.1093/mutage/ger081

• NF-KAPPA-B
• NOD-LIKE RECEPTORS
• IMMUNE-RESPONSES
• INNATE IMMUNITY
• CROHNS-DISEASE
• KINASE
• ACTIVATION
• PATHWAY
• PROTEIN
• TLRS

The aim of this study was to investigate the association of receptor interacting protein 2 (RIP2) single-nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. A case-control study was performed on the SNPs rs16900617 and rs16900627 in 590 Chinese SLE patients and 660 healthy controls. These SNPs were typed by TaqMan allele discrimination assays. We found a significant association of rs16900617 G allele [odds ratio (OR) = 0.54, 95% confidence interval (CI) 0.41-0.72] and rs16900627 G allele (OR = 1.28, 95% CI 1.04-1.58) with SLE. Significant differences in genotype frequency distribution were also found in SLE and control individuals (rs16900617: AG versus AA, OR = 0.59, 95% CI 0.44-0.81; GG versus AA, OR = 0.08, 95% CI 0.01-0.65; AG + GG versus AA, OR = 0.55, 95% CI 0.41-0.75; rs16900627: AG versus AA, OR = 1.51, 95% CI 1.17-1.93; AG + GG versus AA, OR = 1.43, 95% CI 1.13-1.82). Analysis of the haplotypes revealed that two haplotypes of AG and GA were also significantly associated with SLE (OR = 1.37, 95% CI 1.11-1.70; OR = 0.60, 95% CI 0.45-0.79). Our findings suggest that the RIP2 gene polymorphisms may be associated with susceptibility to SLE in the Chinese population.

• 出版日期2012-5
• 单位安徽省立医院; 安徽医科大学