Diastereoselective Synthesis of beta-Piperonyl-gamma-Butyrolactones from Morita-Baylis-Hillman Adducts. Highly Efficient Synthesis of (+/-)-Yatein, (+/-)-Podorhizol and (+/-)-epi-Podorhizol

作者：Trazzi Giordano; Andre Marcelo Fabiano; Coelho Fernando^*

来源：Journal of the Brazilian Chemical Society, 2010, 21(12): 2327-2339.

DOI：10.1590/S0103-50532010001200021

• Morita-Baylis-Hillman
• lignans
• diastereoselectivity

Starting from a Morita-Baylis-Hillman adduct we describe a simple and very efficient method for the diastereoselective preparation of hydroxylated beta-piperonyl-gamma-butyrolactones. To exemplify the efficiency of this approach we also describe a highly efficient synthesis for the biologically active lignans (+/-)-yatein, (+/-)-podorhizol and (+/-)-epi-podorhizol.

• 出版日期2010