An efficient Friedel-Crafts alkylation of nitrogen heterocycles catalyzed by antimony trichloride/montmorillonite K-10

作者：Liu Yu Heng; Liu Qiu Shuang; Zhang Zhan Hui^*

来源：Tetrahedron Letters, 2009, 50(8): 916-921.

DOI：10.1016/j.tetlet.2008.12.022

• Epoxides
• Ring opening
• Friedel-Crafts alkylation
• Nitrogen heterocycle
• Indole
• Pyrrole
• Antimony trichloride
• Montmorillonite K-10

It has been found that SbCl(3) supported on montmorillonite K-10 is an efficient and reusable catalyst for Friedel-Crafts alkylation of nitrogen heterocycles such as indoles and pyrroles with epoxides. The reaction gives the corresponding C-alkylated derivatives in good to excellent yields with a high regioselectivity.

• 出版日期2009-2-25
• 单位河北师范大学