Vitamin D and breast cancer: Is there a link?

作者：Stoll F^*; Akladios C Y; Mathelin C

来源：Gynecologie Obstetrique & Fertilite, 2013, 41(4): 242-250.

DOI：10.1016/j.gyobfe.2013.02.002

• 25-hydroxyvitamin D
• Breast cancer risk
• Vitamin D

Objective. - The aim of this review is to know the relationship between breast cancer and vitamin D, synthesised by skin or brought by food or supplementation.
Material and methods. - The selected articles were extracted from the Pubmed database between 1998 and 2012. The keywords used were: "25-hydroxyvitamin D", "breast cancer recurrence", "breast cancer risk", "serum levels of vitamin D", "vitamin D intake". A total of 37 articles were selected.
Results. - The sun exposure, via the skin vitamin D synthesis, is associated with a decreased risk of breast cancer. This decrease seems also likely for food contributions and an over 400 IU per day vitamin D supplementation. An inverse relationship between plasma 25-hydroxyvitamin D (25-OH-D) level and breast cancer risk has been suggested. An increased 25-OH-D level seems associated with a decreased risk of breast cancer recurrence.
Conclusion. - Recommendations concerning a vitamin D supplementation could be established, but should be supported by additional studies.

• 出版日期2013-4