Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics

作者：Walker Douglas I; Mallon Timothy M; Hopke Philip K; Uppal Karan; Go Young Mi; Rohrbeck Patricia; Pennell Kurt D; Jones Dean P

来源：Journal of Occupational and Environmental Medicine, 2016, 58(8): S12-S21.

DOI：10.1097/JOM.0000000000000768

Objective: The aim of this study was to assess the suitability of high-resolution Pmetabolomics (HRM) for measure of internal exposure and effect biomarkers fromdeployment-related environmental hazards. Methods: HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent applications of HRM as a prototype environmental exposure surveillance system. Results: Building upon techniques available for contemporary occupational medicine and exposure sciences, HRM methods are able to integrate external exposures, internal body burden of environmental agents, and relevant biological responses with health outcomes. Conclusions: Systematic analysis of existing Department of Defense Serum Repository samples will provide a high-quality, cross-sectional reference dataset for deployment-associated exposures while at the same time establishing a foundation for precision medicine.

• 出版日期2016-8