Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium

作者：Sammeta Neeraja; Hardin Debra L; McClintock Timothy S^*

来源：Molecular and Cellular Neuroscience, 2010, 45(4): 398-407.

DOI：10.1016/j.mcn.2010.07.013

• Tle3
• Umodl1
• Kcnc4
• Neural development
• Neurogenesis
• Olfaction

Uncx (Phd1 Chx4) is a paired homeobox transcription factor gene It and its probable functional partners Tle co repressors were expressed by neurally-fated basal progenitor cells and olfactory sensory neurons of the olfactory epithelium Uncx expression was rare in olfactory epithelia of Ascl1(-/-) mice but common in Neurog1(-/-) mice In Uncx(-/-) mice olfactory progenitor cell proliferation progenitor cell number olfactory sensory neuron survival and Umodl1 and Kcnc4 mRNAs were reduced Evidence of sensory neuron activity and functional connections to the olfactory bulb argue that decreased neuronal survival was not due to loss of trophic support or activity-dependent mechanisms These data suggest that U

• 出版日期2010-12