Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)

作者：Park Hyun T; Cho Geum J; Ahn Ki H; Shin Jung H; Kim Young T; Hur Jun Y; Kim Sun H; Lee Kyu W; Kim Tak

来源：Clinical Endocrinology, 2010, 72(1): 26-31.

DOI：10.1111/j.1365-2265.2009.03614.x

P>Objective
To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS).
Design/patients/measurements
We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles.
Results
Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH.
Conclusion
An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.

• 出版日期2010-1