Phenotype-first screening for the identification of novel drug targets

作者：Austen M^*; Dohrmann C

来源：Drug Discovery Today, 2005, 10(4): 275-282.

DOI：10.1016/S1359-6446(05)03368-4

Modem drug discovery is predominantly a target-driven process, where success is intricately linked to the selection of an appropriate molecular target. Ideally, there is conclusive functional evidence that a selected target is disease-relevant and, furthermore, suitable for drug development. Phenotype-first screening is a highly attractive approach for target identification because it offers the unique possibility to analyse entire genomes in an unbiased fashion for disease-related phenotypes. Various studies have demonstrated that phenotype-first screening can be successfully applied to the identification of drug targets, thus establishing this approach as a valuable tool for future target discovery efforts.

• 出版日期2005-2-15