High-temporal-resolution, full-field optical angiography based on short-time modulation depth for vascular occlusion tests

作者：Liao, Riwei; Wang, Mingyi; Han, Dingan; Huang, Zuohua; Zeng, Yaguang^*

来源：Journal of Biomedical Optics, 2016, 21(8): 086002.

DOI：10.1117/1.JBO.21.8.086002

• modulation depth
• laser speckle
• microcirculation

We developed high-temporal-resolution, full-field optical angiography for use in vascular occlusion tests (VOTs). In the proposed method, undersampled signals are acquired by a high-speed digital camera that separates the dynamic and static speckle signals. The two types of speckle signal are used to calculate the short-time modulation depth (STMD) of each of the camera pixels. STMD is then used to realize high-temporal-resolution, full-field optical angiography. Phantom and biological experiments conducted and demonstrated the feasibility of using our proposed method to perform VOTs and to study the reaction kinetics in microfluidic systems.

• 出版日期2016-8
• 单位佛山科学技术学院; 华南师范大学