A novel pressure difference-induced perforation aortic stent-grafts system: an experimental study

作者：Deng Guo-yu; Zhou Jian; Lu Qing-sheng; Wang Lu; Hou Le-wei; Dong Jian; Wang Jian-nan; Zhang Shu-ming; Zhao Zhi-qing; Jing Zai-ping^*

来源：Chinese Medical Journal, 2013, 126(7): 1264-1268.

DOI：10.3760/cma.j.issn.0366-6999.20122272

• aorta
• left subclavian artery
• stent-graft
• pressure difference
• mock circulation

Background Most of endovascular stent-graft modifications to preserve side branch must be customized according to extensive pre-operative assessment, which may not be possible in many hospitals and emergency settings. The study was to develop a novel stent-grafts system that would allow in situ "fenestration", with less reliance on preoperative imaging.
Methods The magnitude of pressure difference (PD) between left subclavian artery (LSA) and aortic arch were measured in 12 experimental pigs. Changes of PD before and after LSA was covered were analyzed respectively. The novel stent graft was made by multi-dimensional and multiple textiles forming technology. According to the PD measurement in pigs, we evaluated the feasibility of the stent-graft in a mock circulation system.
Results In pigs, the blood pressure of aortic arch was significantly higher than that of LSA after it was covered (P <0.001) and PD was (42.78 +/- 5.17) mmHg. After target vessel was covered and when PD between the LSA and aorta reached the magnitude measured in pigs, contrast media oozed from the cranny of graft to the LSA, which was generated by sliding and deformation of yarns of novel stent-graft.
Conclusions The study proposes the design of pressure difference-induced perforation aortic stent-grafts system and verifies that the PD between LSA and aortic arch is high enough to allow in situ "fenestration" by stent graft made by multi-dimensional and multiple textiles forming technology.

• 出版日期2013-4-5
• 单位中国人民解放军第二军医大学; 东华大学