Anticoagulation therapy in atrial fibrillation after intracranial hemorrhage

作者：Park Young Ah; Uhm Jae Sun; Pak Hui Nam; Lee Moon Hyoung; Joung Boyoung^*

来源：Heart Rhythm, 2016, 13(9): 1794-1802.

DOI：10.1016/j.hrthm.2016.05.016

• Intracranial hemorrhage
• Bleeding
• Thromboembolic events
• Anticoagulation
• Atrial fibrillation

BACKGROUND The effect of oral anticoagulation therapy (OAT) in patients with atrial fibrillation (AF) with a history of intracranial hemorrhage (ICH) is poorly defined.
OBJECTIVE The purpose of this study was to evaluate the efficacy and safety of OAT in patients with AF with an ICH history.
METHODS We retrospectively compared the composite end point, including thromboembolic and major bleeding events, between patients with AF with a history of ICH who were (OAT group, n = 254) and those who were not (no-OAT group, n = 174) taking OAT.
RESULTS During a mean follow-up of 39.5 +/- 31.9 months, 5.5 and 3.1 major bleeding events/100 patient-years were observed in the OAT and no-OAT groups, respectively (P = .024). Recurrent ICH was observed only in patient with OAT. Thromboembolic events occurred in 2.4 and 8.3 events/100 patient-years in OAT and no-OAT groups, respectively (P < .001). There was no significant differences in composite end points between OAT and no-OAT groups (11.5 events/100 patient-years vs 7.9 events/100 patient-years; P = .154). Patients with OAT who achieved a time-in-therapeutic range of >= 60% of the international normalized ratio of 2.0-3.0 demonstrated a better cumulative survival free of the composite end point (P < .001) than did patients without OAT. Early (<2 weeks) OAT after an index ICH did not improve composite end points because of the increased incidence of major bleeding events. However, OAT at 2 weeks after an index ICH was associated with decreased clinical events including thromboembolic events and composite end point.
CONCLUSION In patients with AF who require anticoagulation and have a history of ICH, maintaining optimal OAT wi

• 出版日期2016-9