Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway

作者：Wan Guohui; Mathur Rohit; Hu Xiaoxiao; Liu Yunhua; Zhang Xinna; Peng Guang; Lu Xiongbin^*

来源：Cellular Signalling, 2013, 25(5): 1086-1095.

DOI：10.1016/j.cellsig.2013.02.006

• Long non-coding RNA
• ANRIL
• CDKN2B-AS
• ATM
• E2F1
• DNA damage response

The maintenance of genome integrity is essential for the proper function and survival of all organisms. Human cells have evolved prompt and efficient DNA damage response to eliminate the detrimental effects of DNA lesions. The DNA damage response involves a complex network of processes that detect and repair DNA damage, in which long non-coding RNAs (IncRNAs), a new class of regulatory RNAs, may play important roles. Recent studies have identified a large number of IncRNAs in mammalian transcriptomes. However, little is known about the regulation and function of IncRNAs in the DNA damage response. In the present study, we demonstrate that one specific IncRNA, ANRIL, is transcriptionally up-regulated by the transcription factor E2F1 in an ATM-dependent manner following DNA damage, and elevated levels of ANRIL suppress the expression of INK4a, INK4b and ARF at the late-stage of DNA damage response, allowing the cell to return to normal at the completion of the DNA repair.

• 出版日期2013-5