Mechanochemical Solvent-Free and Catalyst-Free One-Pot Synthesis of Pyrano[2,3-d]Pyrimidine-2,4(1H,3H)-Diones with Quantitative Yields

作者：Mashkouri Sara; Naimi Jamal M Reza^*

来源：Molecules, 2009, 14(1): 474-479.

DOI：10.3390/molecules14010474

• Solvent-free reaction
• Barbituric acid
• Pyrimidinediones
• Heterocyclic compounds
• Ball-milling

Solvent-free synthesis of pyrano[2,3-d]pyrimidine-2,4(1H,3H)-diones by ball-milling and without any catalyst is described. This method provides several advantages such as being environmentally friendly, using a simple workup procedure, and affording high yields.

• 出版日期2009-1