Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation

作者：Gordeuk Victor R; Lovato Laura; Barton James C; Vitolins Mara; McLaren Gordon; Acton Ronald T; McLaren Christine; Harris Emily L; Speechley Mark; Eckfeldt John H; Diaz Sharmin; Sholinsky Phyliss; Adams Paul^*

来源：Canadian Journal of Gastroenterology, 2012, 26(6): 345-349.

DOI：10.1155/2012/676824

• Haemochromatosis
• Hemochromatosis
• Iron overload
• Iron supplementation

VR Gordeuk, L Lovato, JC Barton, et al. Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation. Can J Gastroenterol 2012;26(6):345-349. %26lt;br%26gt;BACKGROUND: (HFEY)-Y-C282 homozygotes have an increased risk for developing increased iron stores and related disorders. It is controversial whether dietary iron restrictions should be recommended to such individuals. %26lt;br%26gt;OBJECTIVE: To determine whether dietary iron content influences iron stores in HFEC282Y homozygotes as assessed by serum ferritin concentration. %26lt;br%26gt;DESIGN: Serum ferritin concentration was measured and a dietary iron questionnaire was completed as part of the evaluation of 213 HFEC282Y homozygotes who were identified through screening of %26gt;100,000 primary care patients at five HEmochromatosis and IRon Overload Screening (HEIRS) Study Field Centers in the United States and Canada. %26lt;br%26gt;RESULTS: No significant relationships between serum ferritin concentration and dietary heme iron content, dietary nonheme iron content or reports of supplemental iron use were found. %26lt;br%26gt;CONCLUSION: These results do not support recommending dietary heme or nonheme iron restrictions for HFEC282Y homozygotes diagnosed through screening in North America.

• 出版日期2012-6