Analysis of association between sunscreens use and risk of malignant melanoma

作者：Xie, Fang; Xie, Tingting; Song, Qi; Xia, Shan; Li, Hengjin^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(2): 2378-2384.

• Sunscreens
• malignant melanoma
• meta-analysis

Background: Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma. Methods: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test. Results: Twenty-one studies including 7150 malignant melanoma cases about sunscreens use with the risk of malignant melanoma were included in this meta-analysis. The combined relative risk (RR) of malignant melanoma associated with sunscreens use was 1.145 (95% CI= 0.912-1.438). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found. Conclusions: Our analysis indicated that sunscreens use is not associated with the risk of malignant melanoma.

• 出版日期2015
• 单位中国人民解放军总医院; 中国医科大学