Advancing research diagnostic criteria for Alzheimer%26apos;s disease: the IWG-2 criteria

作者：Dubois Bruno^*; Feldman Howard H; Jacova Claudia; Hampel Harald; Molinuevo Jose Luis; Blennow Kaj; Dekosky Steven T; Gauthier Serge; Selkoe Dennis; Bateman Randall; Cappa Stefano; Crutch Sebastian; Engelborghs Sebastiaan; Frisoni Giovanni B; Fox Nick C; Galasko Douglas; Habert Marie Odile; Jicha Gregory A; Nordberg Agneta; Pasquier Florence; Rabinovici Gil; Robert Philippe; Rowe Christopher; Salloway Stephen; Sarazin Marie; Epelbaum Stephane; de Souza Leonardo C

来源：Lancet Neurology, 2014, 13(6): 614-629.

DOI：10.1016/S1474-4422(14)70090-0

In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging Alzheimer%26apos;s Association have contributed criteria for the diagnosis of Alzheimer%26apos;s disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer%26apos;s pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fiuorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the predinical states of AD.

• 出版日期2014-6
• 单位McGill