Antioxidant and Hepatoprotective Activities of beta-N-Cyanoethyl Acyl Hydrazides Derivatives

作者：Shujaat S^*; Makhmoor T; Naheed S; Choudhary M I

来源：Asian Journal of Chemistry, 2010, 22(6): 4567-4572.

• beta-N-Cyanoethyl acyl hydrazides
• Antioxidant
• DPPH radical
• Hepatoprotective

In the present study, beta-N-cyanoethyl acyl hydrazides derivatives 1-9 were investigated for antioxidant and hepatoprotective properties. Compounds 2, 3, 5-8 exhibited significant free radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radicals, while rest of the compounds 1,4 and 9 have shown moderate activities. Hepatoprotective activity of these compounds was investigated in carbon tetrachloride induced liver toxicity model. Animals were pretreated at a dose level of 10 mg/Kg body weight. before the injection of carbon tetrachloride and serium was analyzed after 48 h of carbon tetrachloride induced hepatotoxicity model in Wistar rats. Results showed that the levels of serum biochemical parameters sAST, sALT and bilirubins were largely maintained (p < 0.05) by most of the compounds (3-6 and 8) as compared to pathological control. In conclusion these beta-N-cyanoethyl acyl, hydrazides derivatives showed both antioxidant and hepatoprotective potential.

• 出版日期2010-6