Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

作者：Ranta Susanna^*; Tuckuviene Ruta; Makipernaa Anne; Albertsen Birgitte K; Frisk Tony; Tedgard Ulf; Jonsson Olafur G; Pruunsild Kaie; Andersson Nadine Gretenkort; Gunnes Maria Winther; Trakymiene Sonata Saulyte; Frandsen Thomas; Heyman Mats; Ruud Ellen; Helgestad Jon

来源：British Journal of Haematology, 2015, 168(4): 547-552.

DOI：10.1111/bjh.13162

• cerebral sinovenous thrombosis
• acute leukaemia
• paediatric

We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

• 出版日期2015-2