Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

作者：Goldsmith Chloe D^*; Vuong Quan V; Sadeqzadeh Elham; Stathopoulos Costas E; Roach Paul D; Scarlett Christopher J

来源：Molecules, 2015, 20(7): 12992-13004.

DOI：10.3390/molecules200712992

• olive leaf
• oleuropein
• pancreatic cancer
• phenolic compounds
• Olea europaea L.
• antioxidant activity
• phytochemicals
• biophenols

Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 mu g/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 mu g/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.

• 出版日期2015-7