FGFR3-TACC3 fusion in solid tumors: mini review

作者：Costa Ricardo; Carneiro Benedito A; Taxter Timothy; Tavora Fabio A; Kalyan Aparna; Pai Sachin A; Chae Young Kwang; Giles Francis J

来源：Oncotarget, 2016, 7(34): 55924-55938.

DOI：10.18632/oncotarget.10482

• FGFR3-TACC3 fusion
• non-small cell lung cancer
• phosphatidylinositol 3-Kinase (PI3K)
• aneuploidy
• glioblastoma multiforme

Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. Furthermore, numerous FGFR inhibitors in clinical development demonstrate the expanding therapeutic relevance of this pathway. Indeed, results from early phase clinical trials already indicate that a subset of patients with advanced tumors derive benefit from FGFR targeted therapies. FGFR gene aberrations and FGFR gene rearrangements are relatively rare in solid malignancies. The recently described FGFR3-TACC3 fusion protein has a constitutively active tyrosine kinase domain and promotes aneuploidy. We summarize the prevalence data on FGFR3-TACC3 fusions among different histological tumor types and the preliminary evidence that this rearrangement represents a targetable molecular aberration in some patients with solid tumors.

• 出版日期2016-8-23
• 单位西北大学