Muscle Matters in Kennedy's Disease

作者：Rinaldi Carlo; Bott Laura C; Fischbeck Kenneth H^*

来源：Neuron, 2014, 82(2): 251-253.

DOI：10.1016/j.neuron.2014.04.005

Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortes et al. (2014) in this issue of Neuron and Lieberman et al. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.

• 出版日期2014-4-16
• 单位NIH