Antihyperglycemic and Antioxidant Activity of Crocin in Streptozotocin-Induced Diabetic Rats

作者：Rajaei Ziba; Hadjzadeh Mousa Al Reza^*; Nemati Habibollah; Hosseini Mahmoud; Ahmadi Marzieh; Shafiee Somayeh

来源：Journal of Medicinal Food, 2013, 16(3): 206-210.

DOI：10.1089/jmf.2012.2407

• crocin
• diabetes
• hyperglycemia
• lipid peroxidation
• oxidative stress
• streptozotocin

The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. The levels of thiobarbituric acid reactive substance (TBARS) and total thiol (SH) groups were measured in the liver and kidney at the end of 6 weeks. Under our experimental conditions, crocin at a dose of 60 mg/kg was found to significantly reduce the blood glucose level in diabetic animals. In addition, there was a significant increase in TBARS levels and decreased total thiol concentrations in the liver and kidney of diabetic animals. Crocin, at doses of 30 and 60 mg/kg, appears to exert an antioxidative activity demonstrated by a lowering of lipid peroxidation levels in these organs. In conclusion, our findings suggest that crocin has the hypoglycemic and antioxidative properties in streptozotocin-induced diabetes and it may be useful in the management of diabetic patients.

• 出版日期2013-3