A Case of Probable MHC Class II Deficiency with Disseminated BCGitis

作者：Alyasin Soheyla; Abolnezhadian Farhad^*; Khoshkhui Maryam

来源：Iranian Journal of Immunology, 2015, 12(3): 219-225.

• BCGosis
• Disseminated BCGitis
• Major Histocompatibility Complex (MHC) Class II
• Deficiency

Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency disease characterized by abnormality of MHC class II molecules surface expression on peripheral blood lymphocytes and monocytes. Clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as SCID (severe combined immunodeficiency), as evidenced by failure to develop disseminated infection after BCG vaccination. Therefore, MHC II deficiency with BCGosis, that is disseminated BCGitis, is not reported commonly. We report an interesting case of BCGosis after vaccination that was diagnosed to have probable MHC II deficiency.

• 出版日期2015-9