New beta-carboline and indole alkaloids from Actinomycete Actinomadura sp BCC 24717

作者：Kornsakulkarn Jittra; Saepua Siri****; Boonruangprapa Tanapong; Suphothina Sumalee; Thongpanchang Chawanee^*

来源：Phytochemistry Letters, 2013, 6(3): 491-494.

DOI：10.1016/j.phytol.2013.06.007

• beta-Carbolines
• Actinomycetes
• Actinomadura
• Bioactive secondary metabolite

Four new beta-carbolines 1-4 and two new indoles 5-6 were isolated together with thirteen known compounds from actinomycete, Actinomadura BCC 24717. Structures of the new compounds, 1-6, were determined by NMR spectroscopic and MS spectrometric analyses. Compound 4 exhibited cytotoxicity to Vero cells and compound 6 showed antifungal activity with IC50 35.91 mu g/mL and 41.97 mu g/mL, respectively.

• 出版日期2013-8