Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism

作者：Domart Marie Charlotte; Benyamina Amine; Lemoine Antoinette; Bourgain Catherine; Blecha Lisa; Debuire Brigitte; Reynaud Michel; Saffroy Raphael^*

来源：ADDICTION BIOLOGY, 2012, 17(4): 783-785.

DOI：10.1111/j.1369-1600.2011.00321.x

• Addiction
• alcohol-dependence
• glutamate
• GRIN2A
• NMDA
• (GT)n repeat

A variable (GT)n repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subjectcontrol analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 x 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.

• 出版日期2012-7