Anti-inflammatory and Antifibrotic Effects of Naringenin in Diabetic Mice

作者：Tsai Shih Jei; Huang Chin Shiu; Mong Mei Chin; Kam Wing Yiu; Huang Hui Ying; Yin Mei Chin^*

来源：Journal of Agricultural and Food Chemistry, 2012, 60(1): 514-521.

DOI：10.1021/jf203259h

• naringenin
• diabetes
• nuclear factor kappa B
• protein kinase C

Renal protective effects of naringenin at 0.5, 1, and 2% of the diet in diabetic mice were examined. Naringenin supplemented at I and 2% increased its deposit in liver and kidney of diabetic mice. Compared with the diabetic control group, naringenin treatments at 1 and 2% lowered plasma levels of glucose and blood urea nitrogen, as well as increased insulin level and creatinine clearance (P %26lt; 0.05). Naringenin treatments dose-dependently reduced renal tumor necrosis factor-alpha level and expression (P %26lt; 0.05) but only at 1 and 2% significantly decreased production and expression of interleukin (IL)-1 beta, IL-6, and monocyte chemoattractant protein-1 (P %26lt; 0.05). Naringenin intake at 2% decreased renal formation and expression of type IV collagen, fibronectin, and transforming growth factor-beta 1 (P %26lt; 0.05). This compound at 1 and 2% lowered protein kinase C activity and suppressed nuclear factor kappa B (NF-kappa B) p65 activity, mRNA expression, and protein production in kidney. However, this agent only at 2% diminished NF-kappa B p50 activity, mRNA expression, and protein production (P %26lt; 0.05). These results indicate that naringenin could attenuate diabetic nephropathy via its anti-inflammatory and antifibrotic activities.

• 出版日期2012-1-11
• 单位中国医科大学