Allelic drop-out probabilities estimated by logistic regression-Further considerations and practical implementation

作者：Tvedebrink Torben^*; Eriksen Poul Svante; Asplund Maria; Mogensen Helle Smidt; Morling Niels

来源：Forensic Science International-Genetics, 2012, 6(2): 263-267.

DOI：10.1016/j.fsigen.2011.06.004

• Allelic drop-out
• Simulations
• PCR cycles
• STR typing
• Forensic genetics

We discuss the model for estimating drop-out probabilities presented by Tvedebrink et al. [7] and the concerns, that have been raised. The criticism of the model has demonstrated that the model is not perfect. However, the model is very useful for advanced forensic genetic work, where allelic drop-out is occurring. With this discussion, we hope to improve the drop-out model, so that it can be used for practical forensic genetics and stimulate further discussions. We discuss how to estimate drop-out probabilities when using a varying number of PCR cycles and other experimental conditions.

• 出版日期2012-3