AKT1 polymorphisms and survival of early stage non-small cell lung cancer

作者：Kim Min Jung; Kang Hyo Gyoung; Lee Shin Yup; Jeon Hyo Sung; Lee Won Kee; Park Ji Young; Lee Eung Bae; Lee Jae Hee; Cha Sung Ick; Kim Dong Sun; Kim Chang Ho; Kam Sin; Jung Tae Hoon; Park Jae Yong

来源：Journal of Surgical Oncology, 2012, 105(2): 167-174.

DOI：10.1002/jso.22071

• AKT1
• non-small cell lung cancer
• polymorphisms
• survival

Background and Objectives: This study was conducted to investigate the impact of polymorphisms in the AKT1 gene on the survival of early stage non-small cell lung cancer (NSCLC) patients. %26lt;br%26gt;Methods:: Three hundred and ten patients with surgically resected NSCLC were enrolled. The rs3803300, rs1130214, rs3730358, rs1130233, and rs2494732 single nucleotide polymorphisms (SNPs) in the AKT1 gene were investigated. The genotype and haplotype associations with overall survival (OS) and disease free survival (DFS) were analyzed. %26lt;br%26gt;Results:: The three SNPs (rs3803300, rs1130214, and rs2494732) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased in a dose- dependent manner as the number of bad genotypes increased (Ptrend %26lt; 1.0 x 10(-4) and 0.001, respectively). Patients with 2 bad genotypes had a significantly worse OS and DFS compared with those with 0 bad genotypes (adjusted hazard ratio (HR) 3.08, 95% confidence interval (CI) -1.61- 5.89, P = 0.001; and adjusted HR 2.04, 95% CI 1.22-3.43, P = 0.01). %26lt;br%26gt;Conclusions:: These results suggest that the AKT1 polymorphisms could be used as prognostic markers for the patients with early-stage NSCLC. J. Surg. Oncol. 2012; 105: 167- 174.

• 出版日期2012-2