Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors

作者：Chen Zhiqiang; Kujawa Sharon G; Sewell William F^*

来源：Nature Neuroscience, 2007, 10(10): 1238-1240.

DOI：10.1038/nn1974

We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.

• 出版日期2007-10