Amphiphilic Homopolymer Vesicles as Unique Nano-Carriers for Cancer Therapy

作者:Mane Shivshankar R; Rao Vijayakameswara N; Chaterjee Koushik; Dinda Himadri; Nag Soma; Kishore Abhinoy; Das Sarma Jayasri*; Shunmugam Raja
来源:Macromolecules, 2012, 45(19): 8037-8042.
DOI:10.1021/ma301644m

摘要

A unique polymersome from amphiphilic, norbornene-derived thiobarbiturate homopolymers (NDTH) and its application as nanocarrier for cancer therapy are elaborately discussed. Various experiments like structural characterizations, control studies, cell viability studies, encapsulation studies, and MTT assay against 4T cancer cells are performed on these NDTH polymersomes to substantiate our claims. All of these results demonstrate that these self-assembled NDTH vesicles have great scope in the world of medicine, and they also symbolize promising carriers for the stimuli-triggered intracellular delivery of hydrophobic drugs.

  • 出版日期2012-10-9