Analysis of degradation data of poly(L-lactide-co-L,D-lactide) and poly(L-lactide) obtained at elevated and physiological temperatures using mathematical models

作者：Han Xiaoxiao; Pan Jingzhe^*; Buchanan Fraser; Weir Neill; Farrar David

来源：Acta Biomaterialia, 2010, 6(10): 3882-3889.

DOI：10.1016/j.actbio.2010.05.015

• Biodegradation
• Resorbable polymers
• Modelling
• Accelerated testing
• Data analysis

The degradation of resorbable polymeric devices often takes months to years Accelerated testing at elevated temperatures is an attractive but controversial technique. The purposes of this paper include (a) to provide a summary of the mathematical models required to analyse accelerated degradation data and to indicate the pitfalls of using these models, (b) to improve the model previously developed by Han and Pan, (c) to provide a simple version of the model of Han and Pan with an analytical solution that is convenient to use: (d) to demonstrate the application of the improved model in two different poly(lactic acid) systems It is shown that the simple analytical relations between molecular weight and degradation time widely used in the literature can lead to Inadequate conclusions In more general situations the rate equations are only part of a complete degradation model.

• 出版日期2010-10