Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population

作者：Tian, Li; Liu, Yinghui; Qin, Yang^*; Long, Shiyin; Xu, Yanhua; Fu, Mingde

来源：Lipids in Health and Disease, 2010, 9(1): 69.

DOI：10.1186/1476-511X-9-69

• CORONARY-HEART-DISEASE
• HDL CHOLESTEROL
• FATTY-ACIDS
• RISK
• LDL
• HYPERCHOLESTEROLEMIA
• SUBFRACTIONS
• TRIGLYCERIDE
• MORTALITY
• TRANSPORT

Background: To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C and HDL-C together with TG on HDL subclass metabolism.
Results: Small-sized pre beta(1)-HDL, HDL3b and HDL3a increased significantly while large-sized HDL2a and HDL2b decreased significantly as the LDL-C/HDL-C ratio increased. The subjects in low HDL-C level (< 1.03 mmol/L) who had an elevation of the LDL-C/HDL-C ratio and a reduction of HDL2b/pre beta(1)-HDL regardless of an undesirable or high LDL-C level. At desirable LDL-C levels (< 3.34 mmol/L), the HDL2b/pre beta(1)-HDL ratio was 5.4 for the subjects with a high HDL-C concentration (>= 1.55 mmol/L); however, at high LDL-C levels (>= 3.36 mmol/L), the ratio of LDL-C/HDL-C was 2.8 in subjects, and an extremely low HDL2b/pre beta(1)-HDL value although with high HDL-C concentration.
Conclusion: With increase of the LDL-C/HDL-C ratio, there was a general shift toward smaller-sized HDL particles, which implied that the maturation process of HDL was blocked. High HDL-C concentrations can regulate the HDL subclass distribution at desirable and borderline LDL-C levels but cannot counteract the influence of high LDL-C levels on HDL subclass distribution.

• 出版日期2010-7-9
• 单位南华大学; 四川大学