Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naive cells in a dendritic cell-independent manner

作者：Lee June Yong; Lim Yu Mi; Park Min Jung; Min So Youn; Cho Mi La; Sung Young Chul; Park Se Ho; Kim Ho Youn; Cho Young Gyu^*

来源：Immunology and Cell Biology, 2008, 86(2): 206-213.

DOI：10.1038/sj.icb.7100127

• TSLP
• DCs
• Treg
• negative selection
• TCR

Human thymic stromal lymphopoietin (TSLP) activates dendritic cells (DCs), which promote the proliferation and differentiation of CD4(+) T cells. However, murine TSLP (mTSLP) can act directly on CD4(+) T cells and bring about their differentiation. We studied the role of mTSLP in the generation of CD4(+)CD25(+)FoxP3(+) T cells from thymocytes. mTSLP promoted the differentiation of CD4(+) single-positive thymocytes into CD4(+)CD25(+)FoxP3(+) T cells. Although we cannot exclude an effect of TSLP mediated through DCs due to co- stimulatory effects, mTSLP appears to act directly on thymocytes. T- cell receptor and TSLP receptor signaling act synergistically on thymocytes to generate CD4(+)CD25(+) FoxP3(+) T cells. mTSLP may play an important role in maintaining immune tolerance by promoting the conversion of thymocytes into natural regulatory T cells via escape from negative selection.

• 出版日期2008-2
• 单位河北医科大学