HHIPL-1 (rs2895811) gene polymorphism is associated with cardiovascular risk factors and cardiometabolic parameters in Mexicans patients with myocardial infarction

作者：Manuel Rodriguez Perez Jose; Posadas Sanchez Rosalinda; Blachman Braun Ruben; Vargas Alarcon Gilberto; Posadas Romero Carlos; Asael Rodriguez Cortes Adrian; Lopez Bautista Fabiola; Alfonso Tovilla Zarate Carlos; Xochitl Rojas Toledo Emma; Marusa Borgonio Cuadra Veronica; Perez Hernandez Nonanzit^*

来源：Gene, 2018, 663: 34-40.

DOI：10.1016/j.gene.2018.04.030

• Hedgehog interacting protein
• Polymorphisms
• Genetic susceptibility
• Myocardial infarction

Several studies have reported the role of hedgehog interacting protein-like 1 (HHIPL-1) in different pathologies, including cardiovascular disease. The aim of the present study was to analyze the association of HHIPL-1 (rs2895811) polymorphism with myocardial infarction (MI), cardiometabolic parameters, and traditional cardiovascular risk factors in the Mexican population. The polymorphism was genotyped using a TaqMan assay in 1023 patients with MI and 1105 controls. A similar distribution of the polymorphism was observed between studied groups. However, in patients group, the C allele was associated with a decreased risk of developing hypertriglyceridemia (OR = 0.757, P-additive = 0.030, OR = 0.685, P-dominant = 0.020, OR = 0.691, P-codominant1 = 0.030), metabolic syndrome (OR = 0.746, P-additive = 0.030, OR = 0.647, P-dominant = 0.005, OR = 0.670, P-heterozygote = 0.015, OR = 0.637, P-codominant1 = 0.005), and insulin resistance (OR = 0.681, P-dominant = 0.045). The results suggest that HHIPL-1 rs2895811 polymorphism is associated with cardiometabolic parameters in Mexican patients with MI.

• 出版日期2018-7-15