摘要

The first gene profiling study of cancer-specific CD8(+) T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations, 1 similar as in %26quot;exhausted%26quot; T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease.

  • 出版日期2012-6