Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects

作者：Roehrs Miguel; Conte Lisiane; da Silva Dariane Trivisiol; Duarte Thiago; Maurer Luana Haselein; Mainardi de Carvalho Jose Antonio; Moresco Rafael Noal; Somdcal Sabrina; Emanuelli Tatiana^*

来源：Food Research International, 2017, 100: 771-779.

DOI：10.1016/j.foodres.2017.08.005

• Bixin
• Norbixin
• Postprandial response
• Cholesterol
• Glycaemia
• Inflammatory cytokines

The aim of this study was to evaluate the effect of annatto carotenoids intake associated to a single high-calorie meal (high fat and high carbohydrate) in postprandial biochemical, inflammatory and oxidative stress markers. Twelve healthy subjects (6 men, 6 women) were included in this randomised, controlled crossover study. Baseline blood samples were collected from fasting subjects that immediately received high-calorie meal without carotenoid (placebo) or containing 1.2 mg/kg bixin (BIX) or 0.06 mg/kg norbixin (NBIX). Blood samples were taken 60, 120 and 240 min after meal intake. NBIX intake did not affect biochemical blood markers but reduced the postprandial levels of inflammatory cytokines (IL-1, IL-6 and TNF-alpha) and lipid oxidation 60-120 min after meal. BIX only partially prevented postprandial-induced lipid oxidation. Results indicate that the intake of NBIX may be an alternative to reduce the postprandial inflammatory and oxidative stress responses to high-calorie meals.

• 出版日期2017-10