A rare case of primary choriocarcinoma in the sigmoid colon

作者：Maehira Hiromitsu; Shimizu Tomoharu^*; Sonoda Hiromichi; Mekata Eiji; Yamaguchi Tomoharo; Miyake Tohru; Ishida Mitsuaki; Tani Tohru

来源：World Journal of Gastroenterology, 2013, 19(39): 6683-6688.

DOI：10.3748/wjg.v19.i39.6683

• Colon cancer
• Colorectal cancer
• Chemotherapy
• Culture drug sensitivity test
• Choriocarcinoma

Primary colorectal choriocarcinoma is an extremely rare neoplasm and is usually associated with a poor prognosis. Only 13 cases of colorectal choriocarcinoma have previously been reported. There is no standard chemotherapeutic regimen for this tumor type. A 68-year-old man presented with melena and was diagnosed with sigmoid colonic adenocarcinoma with multiple liver metastases. He underwent a laparoscopic sigmoidectomy. Pathology revealed choriocarcinoma with a focal component of moderately differentiated adenocarcinoma of colon origin. Based on the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) results, mFOLFOX6 and bevacizumab were administered, which suppressed aggressive tumor growth for 4 mo. The patient died 9 mo after the initial diagnosis. Our study results suggest that the standard chemotherapy regimen for colorectal cancer might have suppressive effects against primary colorectal choriocarcinoma. Moreover, CD-DST may provide, at least in part, therapeutic insight for the selection of appropriate antitumor agents for such patients.

• 出版日期2013-10-21